About 200 of the layoffs will be at the flight simulator maker's headquarters in Montreal, with the other 150 occurring across its civil training network abroad.
The $80-billion Canada Emergency Response Benefit is set to wind down over the coming weeks, with those who are EI-eligible to start drawing assistance that way.
Move comes after chain closed 82 other stores in Canada and all 42 of its stores in the U.S. in early July to focus on its e-commerce business and supplying grocery stores and pharmacies.