Bill Morneau said he had considered leaving his role as finance minister for some time, adding that he never intended to run for a third term as an MP.
Review to look at whether Amazon policies impact sellers' willingness to offer their products at a lower price on other retail channels, such as their own websites or rival online marketplaces.
About 200 of the layoffs will be at the flight simulator maker's headquarters in Montreal, with the other 150 occurring across its civil training network abroad.
The $80-billion Canada Emergency Response Benefit is set to wind down over the coming weeks, with those who are EI-eligible to start drawing assistance that way.
Move comes after chain closed 82 other stores in Canada and all 42 of its stores in the U.S. in early July to focus on its e-commerce business and supplying grocery stores and pharmacies.